Serotonin ELISA

Enzyme immunoassay for the in-vitro diagnostic quantitative determination of Serotonin in human serum, plasma, platelets, urine. Further the test can be used for research of tissue homogenates and cell culture supernatants.Serotonin is an intermediate product of tryptophan metabolism and is located primarily in the enterochromaffin cells of intestine, serotonergic neurons of the brain, platelets of the blood and is well established as a neurotransmitter in the central nervous system. Nearly all of the serotonin in circulating blood is concentrated in platelets. Altered concentrations of circulating serotonin have been implicated in several pathological conditions including chronic tension headache, schizophrenia, hypertension, Huntington´s disease, Duchenne´s muscular dystrophy and early acute appendicitis. The determination of serum serotonin levels is of high clinical significance for diagnostic assessment of carcinoid syndrome. An increasing interest in the determination of serotonin in platelets including uptake and release kinetics is expected in the near future.